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. 1990 Jul;58(7):2397-400.
doi: 10.1128/iai.58.7.2397-2400.1990.

Differential inhibition of lipopolysaccharide-induced phenomena by anti-tumor necrosis factor alpha antibody

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Differential inhibition of lipopolysaccharide-induced phenomena by anti-tumor necrosis factor alpha antibody

S N Vogel et al. Infect Immun. 1990 Jul.

Abstract

Tumor necrosis factor alpha (TNF alpha) has been implicated as a major mediator of lipopolysaccharide (LPS)-induced phenomena. Administration to mice of a polyclonal, monospecific antibody prepared against recombinant murine TNF alpha abolished detection of LPS-induced TNF alpha activity and significantly reduced levels of LPS-induced colony-stimulating factor but failed to reduce the production of LPS-induced interferon, corticosterone, or LPS-induced hypoglycemia.

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