Systemic inflammatory markers and risk of dementia
- PMID: 16948290
- PMCID: PMC10833275
- DOI: 10.1177/1533317506289260
Systemic inflammatory markers and risk of dementia
Abstract
Inflammation plays an important role in the pathogenesis of Alzheimer's disease. This article reviews the results of prospective studies demonstrating that the level of systemic inflammation markers, particularly C-reactive protein and interleukin-6, can predict cognitive decline or dementia. The potential mechanisms linking systemic inflammatory molecules to cognitive decline are also discussed.
References
-
- Eikelenboom P, Bate C, Van Gool WA, etal;. Neuroinflammation in Alzheimer's disease and prion disease. Glia. 2002;40:232-239. - PubMed
-
- Cagnin A, Brooks DJ, Kennedy AM, et al. In-vivo measurement of activated microglia in dementia. Lancet. 2001;358:461-467. - PubMed
-
- Wenk GL. Inflammation in Alzheimer's disease: its role and an opportunity for therapy. Brain Aging. 2003;3:16-20.
-
- Schmidt R, Schmidt H, Curb JD, Masaki K, White LR, Launer LJ. Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia Aging Study. Ann Neurol. 2002;52:168-174. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
