Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1990 Apr;81(4):388-95.
doi: 10.1111/j.1349-7006.1990.tb02580.x.

Griffonia simplicifolia agglutinin-2-binding glycoprotein as a novel carbohydrate antigen of human colonic carcinoma

J Nakayama  1 , A Okano, H Maeda, M Miyachi, H Ota, T Katsuyama, M Kanai
Affiliations
Comparative Study

Griffonia simplicifolia agglutinin-2-binding glycoprotein as a novel carbohydrate antigen of human colonic carcinoma

J Nakayama et al. Jpn J Cancer Res. 1990 Apr.

Abstract

Griffonia simplicifolia agglutinin-2-binding glycoprotein (GBG) in human colonic carcinoma was examined immunochemically and histochemically, GBG was extracted from colonic carcinoma as a serum-type glycoprotein of 160 kilodaltons. GBG was not identical with carcinoembryonic antigen (CEA), since its molecular weight and localization in tissue sections were different from those of CEA. The non-reducing terminals of GBG probably carry N-acetylglucosamine, but not blood group determinants. Furthermore, GBG was released by phosphatidylinositol-specific phospholipase C from cell membrane. GBG was suggested to be anchored to the membrane via linkage to a glycosyl-phosphatidylinositol molecule. Among colonic carcinoma-associated antigens, serum-type glycoproteins having N-acetylglucosamine at non-reducing terminals have not previously been reported. GBG is a novel carbohydrate antigen of human colonic carcinoma.

PubMed Disclaimer

References

    1. ) Hakomori , S. and Kannagi , R.Glycosphingolipids as tumor‐associated and differentiation markers . J. Natl. Cancer Inst. , 71 , 231 – 251 ( 1983. ). - PubMed
    1. ) Feizi , T. and Childs , R. A.Carbohydrates as antigenic determinants of glycoproteins . Biochem. J. , 245 , 1 – 11 ( 1987. ). - PMC - PubMed
    1. ) Lloyd , K. O.Phillip Levine Award Lecture. Blood group antigens as markers for normal differentiation and malignant change in human tissue . Am. J. Clin. Pathol. , 87 , 129 – 137 ( 1987. ). - PubMed
    1. ) Taki , T. and Matsumoto , M.Oncogenic alterations of glycosphingolipids and their molecular antibodies . Seikagaku , 61 , 177 – 193 ( 1989. ) ( in Japanese ). - PubMed
    1. ) Matsushita , Y. , Yonezawa , S. , Nakamura , T. , Shimizu , S. , Ozawa M. , Muramatsu , T. and Sato , E.Carcinoma‐specific Ulex europaeus agglutinin‐I binding glycoproteins of human colorectal carcinoma and its relation to carcinoembryonic antigen . J. Natl. Cancer Inst. , 75 , 219 – 226 ( 1985. ). - PubMed

Publication types

MeSH terms

LinkOut - more resources