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Randomized Controlled Trial
. 2006 Sep 2:5:24.
doi: 10.1186/1476-511X-5-24.

The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome

Julius Oben  1 , Dieudonne Kuate, Gabriel Agbor, Claudia Momo, Xavio Talla
Affiliations
Randomized Controlled Trial

The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome

Julius Oben et al. Lipids Health Dis. .

Abstract

Aim: Once considered a problem of developed countries, obesity and obesity-related complications (such as metabolic syndrome) are rapidly spreading around the globe. The purpose of the present study was to investigate the use of a Cissus quadrangularis formulation in the management of metabolic syndrome, particularly weight loss and central obesity.

Methods: The study was a randomized, double-blind, placebo-controlled design involving 123 overweight and obese persons (47.2% male; 52.8% female; ages 19-50). The 92 obese (BMI >30) participants were randomized into three groups; placebo, formulation/no diet, and formulation/diet (2100-2200 calories/day). The 31 overweight participants (BMI = 25-29) formed a fourth (no diet) treatment group. All participants received two daily doses of the formulation or placebo and remained on a normal or calorie-controlled diet for 8 weeks.

Results: At the end of the trial period, statistically significant net reductions in weight and central obesity, as well as in fasting blood glucose, total cholesterol, LDL-cholesterol, triglycerides, and C-reactive protein were observed in participants who received the formulation, regardless of diet.

Conclusion: Cissus quadrangularis formulation appears to be useful in the management of weight loss and metabolic syndrome.

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