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. 2006 Nov 15;16(22):5844-8.
doi: 10.1016/j.bmcl.2006.08.065. Epub 2006 Sep 1.

Effects of alpha-substitutions on structure and biological activity of anticancer chalcones

Nicholas J Lawrence  1 , Richard P Patterson, Li-Ling Ooi, Darren Cook, Sylvie Ducki
Affiliations

Effects of alpha-substitutions on structure and biological activity of anticancer chalcones

Nicholas J Lawrence et al. Bioorg Med Chem Lett. .

Abstract

Chalcones are known to exhibit antimitotic properties caused by inhibition of tubulin polymerisation. We describe here the effects of different alpha-substitutions, in particular alpha-fluorination, on the structure and biological activity of a series of chalcones.

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