Review
doi: 10.1016/j.molcel.2006.08.002.
Cell signaling and function organized by PB1 domain interactions
Affiliations
- PMID: 16949360
- DOI: 10.1016/j.molcel.2006.08.002
Item in Clipboard
Review
Cell signaling and function organized by PB1 domain interactions
Mol Cell.
.
Free article
Abstract
The PB1-domain-containing proteins p62, aPKC, MEKK2/MEKK3, MEK5, and Par-6 play roles in critical cell processes like osteoclastogenesis, angiogenesis, and early cardiovascular development or cell polarity. PB1 domains are scaffold modules that adopt the topology of ubiquitin-like beta-grasp folds that interact with each other in a front-to-back mode to arrange heterodimers or homo-oligomers. The different PB1 domain adaptors provide specificity for PB1 kinases to ensure the effective transmission of cellular signals. Also, recent data suggest that PB1 domains may serve to orchestrate signaling cascades not involving other PB1 domains, such as the MEK5-ERK5 and p62-ERK1 interactions.
Similar articles
-
PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation.J Biol Chem. 2010 Jan 15;285(3):2077-89. doi: 10.1074/jbc.M109.065102. Epub 2009 Nov 10. J Biol Chem. 2010. PMID: 19903815 Free PMC article.
-
PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway.J Biol Chem. 2003 Sep 26;278(39):36989-92. doi: 10.1074/jbc.C300313200. Epub 2003 Aug 11. J Biol Chem. 2003. PMID: 12912994
-
Signal integration and diversification through the p62 scaffold protein.Trends Biochem Sci. 2007 Feb;32(2):95-100. doi: 10.1016/j.tibs.2006.12.002. Epub 2006 Dec 15. Trends Biochem Sci. 2007. PMID: 17174552 Review.
-
Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins.J Biol Chem. 2003 Sep 5;278(36):34568-81. doi: 10.1074/jbc.M303221200. Epub 2003 Jun 17. J Biol Chem. 2003. PMID: 12813044
-
Structure and function of the PB1 domain, a protein interaction module conserved in animals, fungi, amoebas, and plants.Sci STKE. 2007 Aug 28;2007(401):re6. doi: 10.1126/stke.4012007re6. Sci STKE. 2007. PMID: 17726178 Review.
Cited by
-
Conditional knockout of polarity complex (atypical) PKCι reveals an anti-inflammatory function mediated by NF-κB.Mol Biol Cell. 2016 Jul 15;27(14):2186-97. doi: 10.1091/mbc.E16-02-0086. Epub 2016 May 25. Mol Biol Cell. 2016. PMID: 27226486 Free PMC article.
-
The complex between SOS3 and SOS2 regulatory domain from Arabidopsis thaliana: cloning, expression, purification, crystallization and preliminary X-ray analysis.Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jul 1;63(Pt 7):568-70. doi: 10.1107/S174430910702533X. Epub 2007 Jun 11. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007. PMID: 17620712 Free PMC article.
-
aPKClambda/iota promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6.Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16369-74. doi: 10.1073/pnas.0907044106. Epub 2009 Sep 2. Proc Natl Acad Sci U S A. 2009. PMID: 19805306 Free PMC article.
-
A macrophage NBR1-MEKK3 complex triggers JNK-mediated adipose tissue inflammation in obesity.Cell Metab. 2014 Sep 2;20(3):499-511. doi: 10.1016/j.cmet.2014.06.008. Epub 2014 Jul 17. Cell Metab. 2014. PMID: 25043814 Free PMC article.
-
p62 links the autophagy pathway and the ubiqutin-proteasome system upon ubiquitinated protein degradation.Cell Mol Biol Lett. 2016 Dec 13;21:29. doi: 10.1186/s11658-016-0031-z. eCollection 2016. Cell Mol Biol Lett. 2016. PMID: 28536631 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
