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. 1990 Mar-Apr;20(2):109-13.
doi: 10.1007/BF01268129.

Influence of active immunization of rats with conjugated serotonin-protein antigen on the content of biogenic amines in the brain and on behavioral responses

L A Basharova  1 , L A Vetrilé, V A Evseev, E A Gromova, N V Bobkova, L A Plakzhinas, L E Fast
Affiliations

Influence of active immunization of rats with conjugated serotonin-protein antigen on the content of biogenic amines in the brain and on behavioral responses

L A Basharova et al. Neurosci Behav Physiol. 1990 Mar-Apr.

Abstract

The influence of induction of antibodies to the neuromediator serotonin in the case of active immunization of animals with a conjugate serotonin-protein antigen on the distribution of biogenic amines in the brain and on behavioral responses was investigated in experiments on rats. It was shown that active immunization of rats with a serotonin-protein conjugate leads to a decrease in serotonin, its metabolite 5-hydroxyindole-3-acetic acid, as well as dopamine in certain brain structures. Against a background of induction of antibodies to serotonin, the horizontal motor activity of the animals is decreased.

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