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Review
. 1990;12(1):33-45.
doi: 10.1007/BF00192680.

Fulminant hepatitis

S Sinclair  1 , A Wakefield, G Levy
Affiliations
Review

Fulminant hepatitis

S Sinclair et al. Springer Semin Immunopathol. 1990.

Abstract

In conclusion, evidence exists that cellular and humoral immune-mediated processes result in hepatic necrosis in FH. Activation of the immune coagulation system appears to be an integral part of the inflammatory process resulting in fibrin thrombi which have been demonstrated in the liver, kidneys and lungs of patients with FH. A beneficial role of PG in the treatment of FH has been demonstrated, but controlled trials are required to firmly establish the efficacy of these agents. At present liver transplantation remains the treatment of choice in selected patients with FH. Further studies of the role of the immune system in the pathogenesis of this disease are required to devise more effective therapeutic strategies.

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References

    1. Abecassis M, Falk JA, Makowka L, Dindzans VJ, Falk RE, Levy GA. 16, 16-Dimethyl prostaglandin E2 prevents the development of fulminant hepatitis and blocks the induction of monocyte/macrophage procoagulant activity after murine hepatitis virus strain 3 infection. J Clin Invest. 1987;80:881. - PMC - PubMed
    1. Abecassis M, Falk R, Blendis L, Falk J, Langer B, Greig P, Superina R, Strasberg S, Taylor B, Glynn M, Levy G. Treatment of fulminant hepatic failure with a continuous infusion of Prostin VR (PGE1) (Abstract) Hepatology. 1987;7:1104.
    1. Alp MH, Hickman R. Plasmaphoresis, charcoal and resin perfusion in experimental porcine hepatic failure. Dig Dis Sci. 1986;31:181. - PubMed
    1. Alp MH, Hickman R. The effect of prostaglandins, branched-chain amino acids and other drugs on the outcome of experimental acute porcine hepatic failure. J Hepatol. 1987;4:99. - PubMed
    1. Araki H, Lefer AM. Cytoprotective actions of prostacyclin during hypoxia in the isolated perfused cat liver. Am J Physiol. 1980;238:H176. - PubMed

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