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Case Reports
. 2006 Sep;86(3):719.e15-8.
doi: 10.1016/j.fertnstert.2006.01.055.

Effectiveness of treating ovarian hyperstimulation syndrome with cabergoline in two patients with gonadotropin-producing pituitary adenomas

Mirta Knoepfelmacher  1 , Debora L S Danilovic, Rubia H R Rosa Nasser, Berenice B Mendonça
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Free article
Case Reports

Effectiveness of treating ovarian hyperstimulation syndrome with cabergoline in two patients with gonadotropin-producing pituitary adenomas

Mirta Knoepfelmacher et al. Fertil Steril. 2006 Sep.
Free article

Abstract

Objective: To report the effect of cabergoline on ovarian hyperstimulation syndrome associated with gonadotropin-secreting pituitary adenomas.

Design: Case report.

Setting: Outpatient practice.

Patient(s): Two women with menstrual irregularity, enlarged ovaries, high E(2), and normal gonadotropin levels.

Intervention(s): Cabergoline treatment and transsphenoidal surgery.

Main outcome measure(s): Estradiol levels, transvaginal ultrasonography, and pituitary magnetic resonance imaging. Transsphenoidal surgery showed pituitary adenoma staining for LH in both patients.

Result(s): Cabergoline was effective in reducing E(2) levels and decreasing ovarian size but ineffective in shrinking the pituitary adenomas.

Conclusion(s): This is the first description of the effectiveness of cabergoline as the primary treatment of spontaneous ovarian hyperstimulation syndrome in patients with gonadotropin-producing pituitary adenomas.

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Comment in

  • An important new adaption of a specific drug?
    Manno M, Tomei F, Marchesan E, Adamo V. Manno M, et al. Fertil Steril. 2007 Aug;88(2):533; author reply 533. doi: 10.1016/j.fertnstert.2007.03.025. Epub 2007 Jul 20. Fertil Steril. 2007. PMID: 17644093 No abstract available.

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