A malleable catalyst dominates the metabolism of drugs
- PMID: 16954196
- PMCID: PMC1564253
- DOI: 10.1073/pnas.0606333103
A malleable catalyst dominates the metabolism of drugs
Conflict of interest statement
Conflict of interest statement: No conflicts declared.
Comment on
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Structural basis for ligand promiscuity in cytochrome P450 3A4.Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13682-7. doi: 10.1073/pnas.0603236103. Epub 2006 Sep 5. Proc Natl Acad Sci U S A. 2006. PMID: 16954191 Free PMC article.
References
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- Williams JA, Hyland R, Jones BC, Smith DA, Hurst S, Goosen TC, Peterkin V, Koup JR, Ball SE. Drug Metab Dispos. 2004;32:1201–1208. - PubMed
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- Wienkers LC, Heath TG. Nat Rev Drug Discov. 2005;4:825–833. - PubMed
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- Guengerich FP. In: Cytochrome P450: Structure, Mechanism, and Biochemistry. Ortiz de Montellano P. R., editor. New York: Kluwer Academic/Plenum; 2005. pp. 377–530.
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