doi: 10.1007/BF01969011.
Ischaemia and mediator release: interrelationship in antigen-challenged sensitized guinea-pig kidney
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- PMID: 1695424
- DOI: 10.1007/BF01969011
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Ischaemia and mediator release: interrelationship in antigen-challenged sensitized guinea-pig kidney
Agents Actions.
1990 Apr.
Abstract
Renal vasoconstriction and ischaemia that follow in vitro antigen challenge of isolated perfused kidney of sensitized guinea-pig appears to be a self-perpetuating process, starting with a primary peak of release of vasoconstrictor mediators and followed by secondary peaks (particularly of arachidonic acid metabolites) which are probably initiated by ischaemia/reperfusion damage.
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