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. 1990 Apr;30(1-2):106-9.
doi: 10.1007/BF01969011.

Ischaemia and mediator release: interrelationship in antigen-challenged sensitized guinea-pig kidney

N A Abdullah  1 , E S Assem
Affiliations

Ischaemia and mediator release: interrelationship in antigen-challenged sensitized guinea-pig kidney

N A Abdullah et al. Agents Actions. 1990 Apr.

Abstract

Renal vasoconstriction and ischaemia that follow in vitro antigen challenge of isolated perfused kidney of sensitized guinea-pig appears to be a self-perpetuating process, starting with a primary peak of release of vasoconstrictor mediators and followed by secondary peaks (particularly of arachidonic acid metabolites) which are probably initiated by ischaemia/reperfusion damage.

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