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. 2006 Nov;50(11):3953-5.
doi: 10.1128/AAC.00915-06. Epub 2006 Sep 5.

Prevalence in the United States of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme

Chi Hye Park  1 , Ari Robicsek, George A Jacoby, Daniel Sahm, David C Hooper
Affiliations

Prevalence in the United States of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme

Chi Hye Park et al. Antimicrob Agents Chemother. 2006 Nov.

Abstract

Among 313 Enterobacteriaceae from the United States with a ciprofloxacin MIC of >/=0.25 microg/ml and reduced susceptibility to ceftazidime, aac(6')-Ib was present in 50.5% of isolates, and of these, 28% carried the cr variant responsible for low-level ciprofloxacin resistance. aac(6')-Ib-cr was geographically widespread, stable over time, most common in Escherichia coli, equally prevalent in ciprofloxacin-susceptible and -resistant strains, and not associated with qnr genes.

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References

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