doi: 10.1007/BF01968991.
Modulation of histamine release by rat peritoneal mast cells in a superfusion set-up
Affiliations
- PMID: 1695454
- DOI: 10.1007/BF01968991
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Modulation of histamine release by rat peritoneal mast cells in a superfusion set-up
Agents Actions.
1990 Apr.
Abstract
A new method is presented for studying mediator release in isolated peritoneal cells of the rat. Using a superfusion technique, cells can be maintained in a continuously cleared medium. Cells were stimulated with antigen, compound 48/80 or A23187 to characterize this preparation. In addition, inhibitory effects of theophylline, isoprenaline and cromoglycate on compound 48/80-induced histamine release were studied. We conclude that superfusion is a valid alternative to study mediator release from isolated peritoneal cells.
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