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. 1965 Sep 1;14(1-2):1-11.

Activated human Hageman factor (XII)

R J Speer  1 , H Ridgway, J M Hill
Affiliations
  • PMID: 16955961

Activated human Hageman factor (XII)

R J Speer et al. Thromb Diath Haemorrh. .

Abstract

An improved method for the isolation of highly purified active human Hageman factor has been described. An overall recovery of 25% with a purification of 10(6) has been achieved. Certain of the physical and chemical characteristics of XII have been elucidated. Selective chemical modification of functional groups and a variety of enzymatic assays have been employed in an effort to shed light on the mechanism of action of this procoagulant.

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