Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Aug 1;172(2):645-8.
doi: 10.1084/jem.172.2.645.

Immunoprotective Leishmania major synthetic T cell epitopes

A Jardim  1 , J Alexander, H S Teh, D Ou, R W Olafson
Affiliations

Immunoprotective Leishmania major synthetic T cell epitopes

A Jardim et al. J Exp Med. .

Abstract

Using the predictive algorithm of Rothbard and Taylor (1988. EMBO J. 7:93) and the primary structure of gp63 (Button, L., and M.R. McMaster. 1988. J. Exp. Med. 167:724; Miller, R.A., S.G. Reed, and M. Parsons. 1990. Mol. Biochem. Parasitol. 39:267) we have been able to delineate the structures of a number of gp63 T-cell epitopes which stimulate the proliferation of CD4+ cells. One of these synthetic antigens, inoculated subcutaneously with adjuvant, was shown to specifically induce proliferation of the Th1 subset and provided immunoprotection against two species of Leishmania parasites.

PubMed Disclaimer

References

    1. J Immunol. 1988 Feb 15;140(4):1274-9 - PubMed
    1. J Biol Chem. 1989 May 5;264(13):7483-9 - PubMed
    1. Mol Biochem Parasitol. 1989 Dec;37(2):235-45 - PubMed
    1. Mol Biochem Parasitol. 1990 Mar;39(2):267-74 - PubMed
    1. J Exp Med. 1988 Feb 1;167(2):724-9 - PubMed

Publication types

MeSH terms