Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Nov;44(11):4189-92.
doi: 10.1128/JCM.00796-06. Epub 2006 Sep 6.

Outbreak of infection by carbapenem-resistant Acinetobacter baumannii producing the carbapenemase OXA-58 in Belgium

Pierre Bogaerts  1 , Thierry Naas, Ingrid Wybo, Caroline Bauraing, Oriane Soetens, Denis Piérard, Patrice Nordmann, Youri Glupczynski
Affiliations

Outbreak of infection by carbapenem-resistant Acinetobacter baumannii producing the carbapenemase OXA-58 in Belgium

Pierre Bogaerts et al. J Clin Microbiol. 2006 Nov.

Abstract

Carbapenem-resistant Acinetobacter baumannii isolates were obtained from 17 patients between September 2004 and August 2005 at the Academisch Ziekenhuis Vrije Universiteit Brussel, Brussels, Belgium. These multidrug-resistant isolates, which belonged to a single clone, remained susceptible to colistin and tigecycline only and produced the carbapenem-hydrolyzing oxacillinase OXA-58. This study highlights the importance of the intercountry spread of this beta-lactamase-mediated resistance mechanism and its epidemic evolution.

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
PFGE patterns of A. baumannii isolates. The assigned numbers of A. baumannii isolates are shown over the lanes of the gel and correspond to those in Table 1. The positions of the molecular size markers (lane M; in kilobases) are shown on the left side of the gel. Lanes A, B, and C, OXA-58-producing isolates MAD (18), MAC (15), and SUR (15), respectively, isolated in France.
See this image and copyright information in PMC

References

    1. Afzal-Shah, M., N. Woodford, and D. M. Livermore. 2001. Characterization of OXA-25, OXA-26, and OXA-27, molecular class D beta-lactamases associated with carbapenem resistance in clinical isolates of Acinetobacter baumannii. Antimicrob. Agents Chemother. 45:583-586. - PMC - PubMed
    1. Bergogne-Berezin, E., and K. J. Towner. 1996. Acinetobacter spp. as nosocomial pathogens: microbiological, clinical, and epidemiological features. Clin. Microbiol. Rev. 9:148-165. - PMC - PubMed
    1. Brown, S., and S. Amyes. 2006. OXA β-lactamases in Acinetobacter: the story so far. J. Antimicrob. Chemother. 57:1-3. - PubMed
    1. Brown, S., H. K. Young, and S. G. B. Amyes. 2005. Characterisation of OXA-51, a novel class D carbapenemase found in genetically unrelated clinical strains of Acinetobacter baumannii from Argentina. Clin. Microbiol. Infect. 11:11-15. - PubMed
    1. Clark, R. B. 1996. Imipenem resistance among Acinetobacter baumannii: association with reduced expression of a 33-36 kDa outer membrane protein. J. Antimicrob. Chemother. 38:245-251. - PubMed

Publication types

Substances

LinkOut - more resources