Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1990 Jul 19;346(6281):240-4.
doi: 10.1038/346240a0.

A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif

A H Sinclair  1 , P Berta, M S Palmer, J R Hawkins, B L Griffiths, M J Smith, J W Foster, A M Frischauf, R Lovell-Badge, P N Goodfellow
Affiliations
Comparative Study

A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif

A H Sinclair et al. Nature. .

Abstract

A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene. This gene is conserved and Y-specific among a wide range of mammals, and encodes a testis-specific transcript. It shares homology with the mating-type protein, Mc, from the fission yeast Schizosaccharomyces pombe and a conserved DNA-binding motif present in the nuclear high-mobility-group proteins HMG1 and HMG2. This gene has been termed SRY (for sex-determining region Y) and proposed to be a candidate for the elusive testis-determining gene, TDF.

PubMed Disclaimer

Comment in

Publication types

MeSH terms