Comment on

• Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a.

  Janzen V, Forkert R, Fleming HE, Saito Y, Waring MT, Dombkowski DM, Cheng T, DePinho RA, Sharpless NE, Scadden DT. Janzen V, et al. Nature. 2006 Sep 28;443(7110):421-6. doi: 10.1038/nature05159. Epub 2006 Sep 6. Nature. 2006. PMID: 16957735
• p16INK4a induces an age-dependent decline in islet regenerative potential.

  Krishnamurthy J, Ramsey MR, Ligon KL, Torrice C, Koh A, Bonner-Weir S, Sharpless NE. Krishnamurthy J, et al. Nature. 2006 Sep 28;443(7110):453-7. doi: 10.1038/nature05092. Epub 2006 Sep 6. Nature. 2006. PMID: 16957737
• Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing.

  Molofsky AV, Slutsky SG, Joseph NM, He S, Pardal R, Krishnamurthy J, Sharpless NE, Morrison SJ. Molofsky AV, et al. Nature. 2006 Sep 28;443(7110):448-52. doi: 10.1038/nature05091. Epub 2006 Sep 6. Nature. 2006. PMID: 16957738 Free PMC article.