Comment
doi: 10.1016/j.cell.2006.08.025.
Mind the GAP: Wnt steps onto the mTORC1 train
Affiliations
- PMID: 16959561
- DOI: 10.1016/j.cell.2006.08.025
Item in Clipboard
Comment
Mind the GAP: Wnt steps onto the mTORC1 train
Cell.
.
Free article
Abstract
The TSC1/2 tumor-suppressor complex controls protein synthesis through the regulation of mTOR. In this issue of Cell, Inoki et al. (2006) report that the kinases GSK3 and AMPK cooperate in the activation of TSC2 to inhibit mTOR activity. Surprisingly, the phosphorylation of TSC2 by GSK3 is markedly suppressed by Wnt signaling. This suggests that components of the mTOR pathway may be therapeutic targets for diseases linked to hyperactive Wnt signaling.
Comment on
-
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth.Cell. 2006 Sep 8;126(5):955-68. doi: 10.1016/j.cell.2006.06.055. Cell. 2006. PMID: 16959574
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
