Review
doi: 10.1016/j.molmed.2006.08.009.
Epub 2006 Sep 7.
PEDF: a potential molecular therapeutic target with multiple anti-cancer activities
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- PMID: 16962374
- DOI: 10.1016/j.molmed.2006.08.009
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Review
PEDF: a potential molecular therapeutic target with multiple anti-cancer activities
Trends Mol Med.
2006 Oct.
Abstract
Pigment epithelium-derived factor (PEDF) is an endogenously produced protein that is widely expressed throughout the human body, and exhibits multiple and varied biological activities. Already established as a potent anti-angiogenic molecule, PEDF has recently shown promise as a potential anti-tumour agent, causing both direct and indirect tumour suppression. Here, we explore the unique anti-tumour properties of PEDF and discuss its role as an effective anti-angiogenic, anti-proliferative and pro-differentiation factor. We also discuss the prospects for PEDF therapy and the need for a closer evaluation of issues such as delivery, stability and potential toxicity.
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