Review
doi: 10.1360/yc-006-1180.
[The structure, function and recent reseach of pRNA]
[Article in
Chinese]
Affiliations
- PMID: 16963432
- DOI: 10.1360/yc-006-1180
Item in Clipboard
Review
[The structure, function and recent reseach of pRNA]
[Article in
Chinese]
Yi Chuan.
2006 Sep.
Abstract
In the bacteriophage phi29, a virus-encoded RNA(pRNA) is required for the packaging of its genomic DNA. Six pRNAs form a hexamer through pRNA/pRNA interaction to drive the DNA translocation motor, and ATP as the energy resource. Chimeric pRNAs can steadily combine with siRNA, ribozymes and anti-sense RNA, and then be transferred into the cancer cells and viral-infected cells by RNA nanotechnology. The continued study of pRNA will help us to understand the origin of the life and explore its possible applications.
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