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. 1990;12(1):11-4.

Increased intra-articular substance P and prostaglandin E2 following injection of interleukin-1 in rabbits

E M O'Byrne  1 , V J Blancuzzi, D E Wilson, M Wong, J Peppard, J P Simke, A Y Jeng
Affiliations
  • PMID: 1696566

Increased intra-articular substance P and prostaglandin E2 following injection of interleukin-1 in rabbits

E M O'Byrne et al. Int J Tissue React. 1990.

Abstract

Inflammation was induced by intra-articular injection of 100 ng recombinant human interleukin-1 alpha (rhIL-1) into rabbit knees. Substance P (SP) and prostaglandin E2 (PGE2) were measured by radioimmunoassay (RIA) in the joint fluid at 4, 24 and 48 h after rhIL-1 injection. SP was increased by 4 h, further increased at 24 h and remained elevated at 48 h. PGE2 concentration was highest at 4 h and remained elevated at 48 h after rhIL-1 injection. Because of the proinflammatory activities of SP and PGE2, our studies suggest that the elevated SP and PGE2, in the joint may amplify or sustain an initial receptor-mediated inflammatory response to IL-1.

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