Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Nov;50(11):3917-9.
doi: 10.1128/AAC.00747-06. Epub 2006 Sep 11.

Molecular basis for enhanced activity of posaconazole against Absidia corymbifera and Rhizopus oryzae

Andrew S Chau  1 , Guodong Chen, Paul M McNicholas, Paul A Mann
Affiliations

Molecular basis for enhanced activity of posaconazole against Absidia corymbifera and Rhizopus oryzae

Andrew S Chau et al. Antimicrob Agents Chemother. 2006 Nov.

Abstract

Posaconazole and itraconazole were more potent inhibitors of ergosterol synthesis, in both intact cells and cell extracts from Absidia corymbifera and Rhizopus oryzae, than voriconazole and fluconazole. Similarly, expression of CYP51 from R. oryzae in Saccharomyces cerevisiae significantly increased resistance to fluconazole and voriconazole but not to posaconazole and itraconazole.

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Alignment of CYP51 proteins from Candida albicans (Ca.), CYP51 (accession no. CAA31658); Aspergillus fumigatus (Afum), CYP51A (accession no. AAK73659); Cunninghamella elegans (Celeg), CYP51 (accession no. AAF20263); and Rhizopus oryzae (Roryz). Residues spanning Y132 and F145 from C. albicans are highlighted.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Ballard, S. A., S. L. Kelly, S. W. Ellis, and P. F. Troke. 1990. Interaction of microsomal cytochrome P-450 isolated from Aspergillus fumigatus with fluconazole and itraconazole. J. Med. Vet. Mycol. 28:327-334. - PubMed
    1. Calabrese, D., J. Bille, and D. Sanglard. 2000. A novel multidrug efflux transporter gene of the major facilitator superfamily from Candida albicans (FLU1) conferring resistance to fluconazole. Microbiology 146:2743-2754. - PubMed
    1. Chau, A. S., C. A. Mendrick, F. J. Sabatelli, D. Loebenberg, and P. M. McNicholas. 2004. Application of real-time quantitative PCR to the molecular analysis of Candida albicans strains exhibiting reduced susceptibility to azoles. Antimicrob. Agents Chemother. 48:2124-2131. - PMC - PubMed
    1. Clinical and Laboratory Standards Institute. 2002. Reference method for broth dilution antifungal susceptibility testing of conidium-forming filamentous fungi. Approved standard M38-A. National Committee for Laboratory Standards, Wayne, Pa.
    1. Goldman, G. H., M. E. da Silva Ferreiraqq, Edos Reis Marques, M. Savoldi, D. Perlin, S. Park, P. C. Godoy Martinez, M. H. Goldman, and A. L. Colombo. 2004. Evaluation of fluconazole resistance mechanisms in Candida albicans clinical isolates from HIV-infected patients in Brazil. Diagn. Microbiol. Infect. Dis. 501:25-32. - PubMed

MeSH terms

LinkOut - more resources