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. 2006 Nov;50(11):3917-9.
doi: 10.1128/AAC.00747-06. Epub 2006 Sep 11.

Molecular basis for enhanced activity of posaconazole against Absidia corymbifera and Rhizopus oryzae

Andrew S Chau  1 , Guodong Chen, Paul M McNicholas, Paul A Mann
Affiliations

Molecular basis for enhanced activity of posaconazole against Absidia corymbifera and Rhizopus oryzae

Andrew S Chau et al. Antimicrob Agents Chemother. 2006 Nov.

Abstract

Posaconazole and itraconazole were more potent inhibitors of ergosterol synthesis, in both intact cells and cell extracts from Absidia corymbifera and Rhizopus oryzae, than voriconazole and fluconazole. Similarly, expression of CYP51 from R. oryzae in Saccharomyces cerevisiae significantly increased resistance to fluconazole and voriconazole but not to posaconazole and itraconazole.

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Figures

FIG. 1.
FIG. 1.
Alignment of CYP51 proteins from Candida albicans (Ca.), CYP51 (accession no. CAA31658); Aspergillus fumigatus (Afum), CYP51A (accession no. AAK73659); Cunninghamella elegans (Celeg), CYP51 (accession no. AAF20263); and Rhizopus oryzae (Roryz). Residues spanning Y132 and F145 from C. albicans are highlighted.
See this image and copyright information in PMC

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