[The risk of yellow fever in travellers]
- PMID: 16967591
[The risk of yellow fever in travellers]
Abstract
Yellow fever is a tropical virus disease characterised by high fever, jaundice, heart and kidney failure, and haemorrhagic diathesis. The causative Flavivirus is endemic in parts of tropical Africa and South America and is transmitted among humans and primates by mosquitoes. The chance that an unvaccinated traveller to West Africa will die of yellow fever is estimated at 1:650 to 1:5000 visitors per month of stay, depending on whether an epidemic occurs. Vaccination with the attenuated yellow fever Asibi 17D virus results in limited virus replication in the body and long-term protection due to the formation of neutralising antibodies. Vaccination is contraindicated in immunocompromised persons. Serious disseminated disease and encephalitis due to infection with the vaccine virus strain are seen more often in the elderly. One should therefore refrain from vaccination in persons over 60 years of age when the risk of infection is negligible. In recent years, the number of yellow fever epidemics has risen substantially, particularly in West Africa and the Amazon region. Reintroduction of yellow fever vaccination in childhood vaccination programmes is necessary in endemic areas to turn the tide of increasing outbreaks of yellow fever.
Similar articles
-
Yellow fever: an update.Lancet Infect Dis. 2001 Aug;1(1):11-20. doi: 10.1016/S1473-3099(01)00016-0. Lancet Infect Dis. 2001. PMID: 11871403 Review.
-
Should yellow fever vaccine be included in the expanded program of immunization in Africa? A cost-effectiveness analysis for Nigeria.Am J Trop Med Hyg. 1993 Feb;48(2):274-99. doi: 10.4269/ajtmh.1993.48.274. Am J Trop Med Hyg. 1993. PMID: 8447531
-
Yellow fever vaccine: recommendations of the Advisory Committee on Immunization Practices (ACIP).MMWR Recomm Rep. 2010 Jul 30;59(RR-7):1-27. MMWR Recomm Rep. 2010. PMID: 20671663
-
Isolation of yellow fever virus from mosquitoes in Misiones province, Argentina.Vector Borne Zoonotic Dis. 2012 Nov;12(11):986-93. doi: 10.1089/vbz.2011.0730. Epub 2012 Oct 1. Vector Borne Zoonotic Dis. 2012. PMID: 23025694
-
Yellow fever: the recurring plague.Crit Rev Clin Lab Sci. 2004;41(4):391-427. doi: 10.1080/10408360490497474. Crit Rev Clin Lab Sci. 2004. PMID: 15487593 Review.
Cited by
-
A fatal yellow fever virus infection in China: description and lessons.Emerg Microbes Infect. 2016 Jul 13;5(7):e69. doi: 10.1038/emi.2016.89. Emerg Microbes Infect. 2016. PMID: 27406389 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical