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. 1990 Aug;81(2):218-24.
doi: 10.1111/j.1365-2249.1990.tb03321.x.

Natural killer cell activity during measles

D E Griffin  1 , B J Ward, E Jauregui, R T Johnson, A Vaisberg
Affiliations

Natural killer cell activity during measles

D E Griffin et al. Clin Exp Immunol. 1990 Aug.

Abstract

Natural killer cells are postulated to play an important role in host anti-viral defences. We measured natural killer cell activity in 30 individuals with acute measles (73 +/- 21 lytic units (LU)/10(7) cells) and 16 individuals with other infectious diseases (149 +/- 95 LU) and found it reduced compared with values for adults (375 +/- 70 LU; P less than 0.001) or children (300 +/- 73 LU, P less than 0.01) without infection. Reduced natural killer cell activity was found in measles patients with (84 +/- 30 LU) and without (55 +/- 18 LU) complications and was present for at least 3 weeks after the onset of the rash. Activity was increased by in vitro exposure of cells to interleukin-2. Depressed natural killer cell activity parallels in time the suppression of other parameters of cell-mediated immunity that occurs during measles.

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References

    1. Pediatr Infect Dis J. 1987 May;6(5):451-4 - PubMed
    1. J Immunol. 1983 Apr;130(4):1970-3 - PubMed
    1. Science. 1984 Jan 13;223(4632):188-90 - PubMed
    1. J Virol. 1984 Feb;49(2):409-12 - PubMed
    1. Clin Immunol Immunopathol. 1981 Aug;20(2):215-23 - PubMed

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