Review
[Advances in the study of steroidogenic acute regulatory protein]
[Article in
Chinese]
Affiliations
- PMID: 16970168
Item in Clipboard
Review
[Advances in the study of steroidogenic acute regulatory protein]
[Article in
Chinese]
Zhonghua Nan Ke Xue.
2006 Aug.
Abstract
The steroidogenic acute regulatory (StAR) protein is an essential component in the regulation of steroid biosynthesis in adrenal and gonadal cells. The StAR protein has a high tissue specificity, located on the mitochondrial membranes of some relative cells. It regulates the transfer of cholesterin from extracellular into intracellular and plays a dominant role in steroidogenic synthesis. Recent studies have also shown that the transcription and expression of StAR are modulated not only through the cAMP-PKA dependent pathway, but also by multiple hormones and cytokines, which contributes to the regulation of cholesterin synthesis.
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