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. 1990 Sep;10(9):5002-6.
doi: 10.1128/mcb.10.9.5002-5006.1990.

Repression of the alpha-fetoprotein gene promoter by progesterone and chimeric receptors in the presence of hormones and antihormones

B Turcotte  1 , M E Meyer, M T Bocquel, L Bélanger, P Chambon
Affiliations

Repression of the alpha-fetoprotein gene promoter by progesterone and chimeric receptors in the presence of hormones and antihormones

B Turcotte et al. Mol Cell Biol. 1990 Sep.

Abstract

Using transient transfection assays, we showed that repression of the alpha-fetoprotein promoter by intact and deletion mutants of the progesterone receptor and by chimeric progesterone/glucocorticoid-estrogen receptors in the presence of their cognate hormones was closely correlated with their ability to bind to a progesterone/glucocorticoid-responsive element. This negative regulation was also observed in the presence of antihormones, providing evidence that receptor-antihormone complexes can bind to their responsive elements in vivo.

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