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Review
. 2006 Oct;28(2):83-96.
doi: 10.1007/s00281-006-0030-7. Epub 2006 Sep 14.

Genetics of SLE in mice

Dwight H Kono  1 , Argyrios N Theofilopoulos
Affiliations
Review

Genetics of SLE in mice

Dwight H Kono et al. Springer Semin Immunopathol. 2006 Oct.

Abstract

Genetic studies in spontaneous, induced, and gene-manipulated mouse models of SLE have provided significant insights into the potential number and diversity of genes that can promote, resist, and modify lupus susceptibility. Novel genes and mechanisms of disease pathogenesis have also been identified. Importantly, mouse models have provided an initial view of the genomic landscape of lupus-affecting genes, and have documented the complexities of verifying and determining the role of specific candidate loci and genes. Mouse models of lupus should continue to serve as a vital approach to defining the genetics of SLE.

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