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Comment
. 2006 Aug;48(4):644-9; discussion 660-2.
doi: 10.1002/bimj.200610242.

How practical are adaptive designs likely to be for confirmatory trials?

A Lawrence Gould  1
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Comment

How practical are adaptive designs likely to be for confirmatory trials?

A Lawrence Gould. Biom J. 2006 Aug.

Abstract

This is a discussion of the following papers appearing in this special issue on adaptive designs: 'Confirmatory Seamless Phase II/III Clinical trials with Hypotheses Selection at Interim: General Concepts' by Frank Bretz, Heinz Schmidli, Franz König, Amy Racine and Willi Maurer; and 'Confirmatory Seamless Phase II/III Clinical Trials with Hypotheses Selection at Interim: Applications and Practical Considerations' by Heinz Schmidli, Frank Bretz, Amy Racine and Willi Maurer.

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