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Comment
. 2006 Aug;48(4):650-5; discussion 660-2.
doi: 10.1002/bimj.200610248.

Confirmatory seamless phase II/III clinical trials with hypotheses selection at interim: opportunities and limitations

Christopher Jenniso  1 , Bruce W Turnbull
Affiliations
Comment

Confirmatory seamless phase II/III clinical trials with hypotheses selection at interim: opportunities and limitations

Christopher Jenniso et al. Biom J. 2006 Aug.

Abstract

This is a discussion of the following two papers in this special issue on adaptive designs: 'Confirmatory seamless phase II/III clinical trials with hypotheses selection at interim: General concepts' by Frank Bretz, Heinz Schmidli, Franz König, Amy Racine and Willi Maurer, and 'Confirmatory seamless phase II/III clinical trials with hypotheses selection at interim: Applications and practical considerations' by Heinz Schmidli, Frank Bretz, Amy Racine and Willi Maurer.

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