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Comment
. 2006 Aug;48(4):656-9; discussion 660-2.
doi: 10.1002/bimj.200610241.

Plan to be flexible: a commentary on adaptive designs

Weichung Joe Shih  1
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Comment

Plan to be flexible: a commentary on adaptive designs

Weichung Joe Shih. Biom J. 2006 Aug.

Abstract

This is a discussion of the following three papers appearing in this special issue on adaptive designs: 'Nested repeated confidence intervals and switching between noninferiority and superiority' by Joachim Hartung and Guido Knapp; 'Confirmatory Seamless Phase II/III Clinical trials with Hypotheses Selection at Interim: General Concepts' by Frank Bretz, Heinz Schmidli, Franz König, Amy Racine and Willi Maurer; and 'Confirmatory Seamless Phase Il/III Clinical Trials with Hypotheses Selection at Interim: Applications and Practical Considerations' by Heinz Schmidli, Frank Bretz, Amy Racine and Willi Maurer.

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