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Review
. 2006 Sep 15;23(6):776-7.
doi: 10.1016/j.molcel.2006.08.022.

HATs off to PIC assembly

B Franklin Pugh  1
Affiliations
Free article
Review

HATs off to PIC assembly

B Franklin Pugh. Mol Cell. .
Free article

Abstract

There are many regulated steps in the assembly of a transcription preinitiation complex (PIC). In this issue of Molecular Cell, Black et. al. (2006) reveal a catalytic switch mechanism in which autoacetylation of the HAT p300 triggers its dissociation from a promoter in a manner that is coupled to TFIID association.

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