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Comment
. 2006 Sep 15;313(5793):1573; author reply 1573.
doi: 10.1126/science.1131729.

Comment on "Large-scale sequence analysis of avian influenza isolates"

Edward C Holmes  1 , David J Lipman, Dmitriy Zamarin, Jonathan W Yewdell
Affiliations
Comment

Comment on "Large-scale sequence analysis of avian influenza isolates"

Edward C Holmes et al. Science. .

Abstract

Obenauer et al. (Research Articles, 17 March 2006, p. 1576) reported that the influenza A virus PB1-F2 gene is evolving under strong positive selection, as documented by an extremely high ratio of the number of nonsynonymous nucleotide substitutions to the number of synonymous substitutions (dN/dS). However, we show that this observation is likely to be an artifact related to the location of PB1-F2 in the +1 reading frame of the PB1 gene.

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Comment on

  • Large-scale sequence analysis of avian influenza isolates.
    Obenauer JC, Denson J, Mehta PK, Su X, Mukatira S, Finkelstein DB, Xu X, Wang J, Ma J, Fan Y, Rakestraw KM, Webster RG, Hoffmann E, Krauss S, Zheng J, Zhang Z, Naeve CW. Obenauer JC, et al. Science. 2006 Mar 17;311(5767):1576-80. doi: 10.1126/science.1121586. Epub 2006 Jan 26. Science. 2006. PMID: 16439620

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