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. 1990 Aug 30;346(6287):818-22.
doi: 10.1038/346818a0.

In vitro selection of RNA molecules that bind specific ligands

A D Ellington  1 , J W Szostak
Affiliations

In vitro selection of RNA molecules that bind specific ligands

A D Ellington et al. Nature. .

Abstract

Subpopulations of RNA molecules that bind specifically to a variety of organic dyes have been isolated from a population of random sequence RNA molecules. Roughly one in 10(10) random sequence RNA molecules folds in such a way as to create a specific binding site for small ligands.

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