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Comparative Study
. 1990 Aug;85(3):267-71.
doi: 10.1007/BF00206743.

Differential bleomycin susceptibility in cultured lymphocytes of fragile X patients and normal individuals

S Y Li  1 , J K Lin
Affiliations
Comparative Study

Differential bleomycin susceptibility in cultured lymphocytes of fragile X patients and normal individuals

S Y Li et al. Hum Genet. 1990 Aug.

Abstract

The frequency of bleomycin-induced chromatid breaks was studied in cultured lymphocytes from ten fragile X patients and ten healthy controls. The results showed that the frequency of chromatid breaks was significantly higher among fragile X patients than among normal individuals. We suggest that the fragile X patients may be more susceptible to mutagens and carcinogens and, therefore, more prepotent to neoplastic induction.

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