Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Aug 31;249(4972):1030-3.
doi: 10.1126/science.1697696.

Adhesion of human B cells to germinal centers in vitro involves VLA-4 and INCAM-110

A S Freedman  1 , J M Munro, G E Rice, M P Bevilacqua, C Morimoto, B W McIntyre, K Rhynhart, J S Pober, L M Nadler
Affiliations

Adhesion of human B cells to germinal centers in vitro involves VLA-4 and INCAM-110

A S Freedman et al. Science. .

Abstract

Human B lymphocytes localize and differentiate within the microenvironment of lymphoid germinal centers. A frozen section binding assay was developed for the identification of those molecules involved in the adhesive interactions between B cells and lymphoid follicles. Activated human B cells and B cell lines were found to selectively adhere to germinal centers. The VLA-4 molecule on the lymphocyte and the adhesion molecule INCAM-110, expressed on follicular dendritic cells, supported this interaction. This cellular interaction model can be used for the study of how B cells differentiate.

PubMed Disclaimer

Publication types

LinkOut - more resources