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. 1990 Sep;81(3):454-8.
doi: 10.1111/j.1365-2249.1990.tb05355.x.

Multiple infusions of human intravenous immunoglobulin in chimpanzees do not lead to immune elimination

H Leibl  1 , H M Wolf, G Eder, J W Mannhalter, M M Eibl
Affiliations

Multiple infusions of human intravenous immunoglobulin in chimpanzees do not lead to immune elimination

H Leibl et al. Clin Exp Immunol. 1990 Sep.

Abstract

Administration of human i.v. immunoglobulins was shown to lead to a permanent increase in IgG1 and IgG2 levels in chimpanzees. Half-lives of human IgG1 and IgG2 in chimpanzees were comparable to those found in humans, and no signs of immune elimination were observed. Furthermore, long-term treatment of chimpanzees had no effect on the percentage of immunoregulatory T cells (CD2+, CD4+ and CD8+ T cells) as determined by FACS analysis. In addition, serum IgM levels in chimpanzees were found to be comparable to those in humans, whereas the chimpanzees' IgG levels are slightly elevated due to higher concentrations of IgG2 and, in particular, IgG4.

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