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. 2006 Oct;49(4):396-405.
doi: 10.1111/j.1365-2559.2006.02515.x.

Pathology of fungal infections of the central nervous system: 17 years' experience from Southern India

C Sundaram  1 , P Umabala, V Laxmi, A K Purohit, V S S V Prasad, M Panigrahi, B P Sahu, M V Sarathi, S Kaul, R Borghain, A K Meena, S S Jayalakshmi, A Suvarna, S Mohandas, J M K Murthy
Affiliations

Pathology of fungal infections of the central nervous system: 17 years' experience from Southern India

C Sundaram et al. Histopathology. 2006 Oct.

Abstract

Aims: To describe the pathology of central nervous system (CNS) fungal infections with particular reference to India.

Methods and results: This was a retrospective study from 1988 to 2004 constituting 130 cases. The diagnosis was based on morphology of biopsy/autopsy material. These included aspergillosis (n=73), zygomycosis (n=40), cryptococcosis (n=2), rhodotorulosis (n=1), candidiasis (n=5), maduramycosis (n=1), pheohyphomycosis (n=3) and mixed infections (n=5). Predisposing risk factors were present in 49 (38%) patients only. The majority of the patients were immunocompetent. The commonest risk factor was diabetes mellitus, the commonest route of infection was from a contiguous site and the commonest pathology was granuloma. Culture positivity was seen in only 31%.

Conclusion: Environmental factors in tropical countries such as India play a significant role in the pathogenesis of CNS fungal infections.

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