Review
doi: 10.1016/j.biopha.2006.07.087.
Epub 2006 Aug 31.
HIV and complement: hijacking an immune defense
Affiliations
- PMID: 16978830
- DOI: 10.1016/j.biopha.2006.07.087
Item in Clipboard
Review
HIV and complement: hijacking an immune defense
Biomed Pharmacother.
2006 Nov.
Abstract
The complement system is a central player of the innate immune system. Activation of the complement system protects the host against pathogens. However, uncontrolled synthesis can be detrimental to host. This concise review summarizes the current understanding of the mechanism(s) of complement activation, the mechanism of C3 regulation, and the role of complement in human immunodeficiency virus (HIV) pathogenesis with emphasis on the cross-talk between HIV and complement system in NeuroAIDS and HIV-associated nephropathy (HIVAN).
Similar articles
-
Human immunodeficiency virus and the complement system.Exp Clin Immunogenet. 1997;14(1):11-5. Exp Clin Immunogenet. 1997. PMID: 9187917 Review. No abstract available.
-
Complement-HIV interactions during all steps of viral pathogenesis.Vaccine. 2008 Jun 6;26(24):3046-54. doi: 10.1016/j.vaccine.2007.12.003. Epub 2007 Dec 26. Vaccine. 2008. PMID: 18191309
-
HIV and direct damage of organs: disease spectrum before and during the highly active antiretroviral therapy era.AIDS. 2003 Apr;17 Suppl 1:S51-64. AIDS. 2003. PMID: 12870531 Review.
-
HIV-1 and HIV-Associated Nephropathy 25 Years Later.Clin J Am Soc Nephrol. 2007 Jul;2 Suppl 1:S20-4. doi: 10.2215/CJN.03561006. Clin J Am Soc Nephrol. 2007. PMID: 17699507 Review.
-
Role of complement in HIV infection.Annu Rev Immunol. 1997;15:649-74. doi: 10.1146/annurev.immunol.15.1.649. Annu Rev Immunol. 1997. PMID: 9143703 Review.
Cited by
-
Complement and Antibody-mediated Enhancement of Red Blood Cell Invasion and Growth of Malaria Parasites.EBioMedicine. 2016 Jul;9:207-216. doi: 10.1016/j.ebiom.2016.05.015. Epub 2016 May 14. EBioMedicine. 2016. PMID: 27333049 Free PMC article.
-
HIV-associated Immune Complex Kidney Disease with C3-dominant Deposition Induced by HIV Infection after Treatment of IgA Nephropathy.Intern Med. 2019 Oct 15;58(20):3001-3007. doi: 10.2169/internalmedicine.2439-18. Epub 2019 Jun 27. Intern Med. 2019. PMID: 31243235 Free PMC article.
-
Regulation of complement component C3 in astrocytes by IL-1beta and morphine.J Neuroimmune Pharmacol. 2008 Mar;3(1):43-51. doi: 10.1007/s11481-007-9096-9. Epub 2007 Nov 14. J Neuroimmune Pharmacol. 2008. PMID: 18247123
-
Role of C/EBP-β, p38 MAPK, and MKK6 in IL-1β-mediated C3 gene regulation in astrocytes.J Cell Biochem. 2011 Apr;112(4):1168-75. doi: 10.1002/jcb.23032. J Cell Biochem. 2011. PMID: 21308746 Free PMC article.
-
Plasma levels of soluble membrane attack complex are elevated despite viral suppression in HIV patients with poor immune reconstitution.Clin Exp Immunol. 2019 Dec;198(3):359-366. doi: 10.1111/cei.13366. Epub 2019 Sep 8. Clin Exp Immunol. 2019. PMID: 31461782 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous
