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. 1990 Sep 14;249(4974):1295-7.
doi: 10.1126/science.1697984.

LFA-3, CD44, and CD45: physiologic triggers of human monocyte TNF and IL-1 release

D S Webb  1 , Y Shimizu, G A Van Seventer, S Shaw, T L Gerrard
Affiliations

LFA-3, CD44, and CD45: physiologic triggers of human monocyte TNF and IL-1 release

D S Webb et al. Science. .

Abstract

The monocyte-derived cytokines, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta), are central regulators of the immune response, but the physiologic stimuli for their release remain largely undefined. Engagement of three monocyte glycoproteins, LFA-3, CD44, and CD45, by specific monoclonal antibodies immobilized on plastic induced TNF-alpha and IL-1 beta release. In addition, TNF-alpha was released when monocyte LFA-3 bound immobilized, purified CD2, which is its physiologic receptor. Thus, a receptor-ligand interaction that mediates cell-cell adhesion can transmit the necessary signals for the release of monokines.

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