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Review
. 2006 Oct;9(5):530-7.
doi: 10.1016/j.pbi.2006.07.014.

Complexity beneath the silence

Myriam Calonje  1 , Z Renee Sung
Affiliations
Review

Complexity beneath the silence

Myriam Calonje et al. Curr Opin Plant Biol. 2006 Oct.

Abstract

Polycomb group (PcG)-mediated silencing by proteins that are conserved across plants and animals is a key feature of eukaryotic gene regulation. Investigation of PcG-mediated gene silencing has revealed a surprising degree of complexity in the molecular mechanisms that recruit the protein complexes, repress expression, and maintain the epigenetic silent state of target genes. This review summarizes our current understanding of the mechanism of PcG-mediated gene silencing in animals and higher plants.

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