Comparative Study
doi: 10.1101/lm.253506.
Epub 2006 Sep 15.
Two mutations preventing PDZ-protein interactions of GluR1 have opposite effects on synaptic plasticity
Affiliations
- PMID: 16980545
- DOI: 10.1101/lm.253506
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Comparative Study
Two mutations preventing PDZ-protein interactions of GluR1 have opposite effects on synaptic plasticity
Learn Mem.
2006 Sep-Oct.
Abstract
The regulated trafficking of GluR1 contributes significantly to synaptic plasticity, but studies addressing the function of the GluR1 C-terminal PDZ-ligand domain in this process have produced conflicting results. Here, we resolve this conflict by showing that apparently similar C-terminal mutations of the GluR1 PDZ-ligand domain result in opposite physiological phenotypes during activity- and CamKII-induced synaptic plasticity.