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Randomized Controlled Trial
. 2006 Oct;39(4):607-9.
doi: 10.1016/j.jadohealth.2006.03.019. Epub 2006 Jul 10.

Challenges of conducting a placebo-controlled trial for dysmenorrhea in adolescents

Anne R Davis  1 , Lauren M Osborne, Katharine J O'Connell, Carolyn L Westhoff
Affiliations
Randomized Controlled Trial

Challenges of conducting a placebo-controlled trial for dysmenorrhea in adolescents

Anne R Davis et al. J Adolesc Health. 2006 Oct.

Abstract

We recruited adolescents to study oral contraceptives versus placebo for dysmenorrhea. We anticipated high discontinuation and concerns about safety, side effects, and sexual behavior. Treatment discontinuation (11%) and loss to follow-up (1%) were lower than expected. The most common reason for nonenrollment was logistical issues (63%). Most participants remained abstinent.

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