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Review
. 2006 Sep;13(6):327-35.
doi: 10.1155/2006/901417.

Mucin overproduction in chronic inflammatory lung disease

Hans-Peter Hauber  1 , Susan C Foley, Qutayba Hamid
Affiliations
Review

Mucin overproduction in chronic inflammatory lung disease

Hans-Peter Hauber et al. Can Respir J. 2006 Sep.

Abstract
in English, French

Mucus overproduction and hypersecretion are commonly observed in chronic inflammatory lung disease. Mucins are gel-forming glycoproteins that can be stimulated by a variety of mediators. The present review addresses the mechanisms involved in the upregulation of secreted mucins. Mucin induction by neutrophil elastase, bacteria, cytokines, growth factors, smoke and cystic fibrosis transmembrane conductance regulator malfunction are also discussed.

La surproduction de mucus et l’hypersécrétion sont courantes en présence d’une pneumopathie inflammatoire chronique. Les mucines sont des glycoprotéines gélifiantes qui peuvent être stimulées par divers médiateurs. La présente analyse traite des mécanismes de régulation positive des mucines sécrétées. Est également exposée l’induction des mucines par l’élastase des neutrophiles, les bactéries, les cytokines, les facteurs de croissance, la fumée et la défaillance du régulateur de conductance trans-membraneuse de la fibrose kystique.

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