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Comment
. 2006 Sep 26;103(39):14259-60.
doi: 10.1073/pnas.0606888103. Epub 2006 Sep 19.

Cryptic messages: is noncoagulant tissue factor reserved for cell signaling?

Eric Camerer  1 , Joann Trejo
Affiliations
Comment

Cryptic messages: is noncoagulant tissue factor reserved for cell signaling?

Eric Camerer et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Model of PDI-induced switch of TF function. Coagulant TF binds factors VIIa and X to facilitate thrombin (IIa) generation. Thrombin promotes coagulation by cleaving and activating PAR1 and PAR4 (important for platelet aggregation) and by cleaving fibrinogen to generate fibrin monomers. Factor Xa can also signal via PAR1 or PAR2 as a monomer or while in a ternary complex with TF:VIIa. PDI reduces TF disulfide bonds to free thiols (SH), which are likely to undergo further modifications, and stabilizes a distinct TF:VIIa form that cannot bind factor X. TF:VIIa:PAR2, perhaps together with PDI, is competent to signal but does not promote coagulation.
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