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Comparative Study
. 1990 Oct;82(1):16-20.
doi: 10.1111/j.1365-2249.1990.tb05397.x.

Epitope mapping of an HLA-B27 monoclonal antibody that also reacts with a 35-kD bacterial outer-membrane protein

A Toubert  1 , M Hamachi, C Raffoux, M S Park, D T Yu
Affiliations
Comparative Study

Epitope mapping of an HLA-B27 monoclonal antibody that also reacts with a 35-kD bacterial outer-membrane protein

A Toubert et al. Clin Exp Immunol. 1990 Oct.

Abstract

Ye-3 is an HLA-B27-specific murine monoclonal antibody recognizing the heat-modifiable protein of Enterobacteriaceae. Here we used recombinant hybrid molecules between the HLA-B7 and HLA-B27 antigens to delineate the epitope recognized by Ye-3. Results of these experiments indicated that the segment of HLA-B*2705 spanning residues 77-81 was critical to the reactive epitope. It is known to be a major serological and functional recognition site of HLA-B*2705 and our data give support for its involvement also in the serological cross-reactivity with bacterial antigens.

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