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. 1975 Jul;32(1):139-41.
doi: 10.1038/bjc.1975.140.

Loss of anti-tumour immunogenicity of a somatic cell hybrid line with increasing subculture

R Favre, Y Carcassonne, G Meyer
Free PMC article

Loss of anti-tumour immunogenicity of a somatic cell hybrid line with increasing subculture

R Favre et al. Br J Cancer. 1975 Jul.
Free PMC article

Abstract

Good immunoprotection was afforded by A9/SEWA somatic hybrid cells in the C3H mouse/C3H Py tumour system, confirming results previously obtained in the A.SW mouse/SEWA tumour system. However, in this study the immunogenicity decreased with increasing serial subculture of the hybrid line and concomitant chromosome loss.

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