Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Sep 28;8(20):4489-92.
doi: 10.1021/ol061751u.

Gold-catalyzed tandem cycloisomerization-hydroalkoxylation of homopropargylic alcohols

Volker Belting  1 , Norbert Krause
Affiliations

Gold-catalyzed tandem cycloisomerization-hydroalkoxylation of homopropargylic alcohols

Volker Belting et al. Org Lett. .

Abstract

The tandem cycloisomerization-hydroalkoxylation of various homopropargylic alcohols in the presence of an alcohol and a dual catalyst system, consisting of a gold precatalyst and a Brønsted acid, provides an efficient route to tetrahydrofuranyl ethers under mild reaction conditions. The reaction can be carried out in various solvents, including alcohol, with both terminal and internal alkynes as the substrate.

PubMed Disclaimer

LinkOut - more resources